01 - Heat a large skillet over medium-high heat. Add ground beef and season with salt, pepper, smoked paprika, and garlic powder. Break up meat and cook until browned, about 7-8 minutes. Drain excess fat if needed.
02 - Whisk together mayonnaise, ketchup, mustard, pickle relish, apple cider vinegar, smoked paprika, salt, and pepper in a small bowl until smooth. Set aside.
03 - Divide chopped romaine lettuce evenly among four large serving bowls.
04 - Top each bowl with equal portions of cooked ground beef, cherry tomatoes, shredded cheddar cheese, red onion slices, pickle slices, and diced avocado.
05 - Drizzle each bowl with prepared burger sauce immediately before serving.