01 - In a small bowl, combine the salt, black pepper, paprika, garlic powder, and onion powder until evenly incorporated.
02 - Sprinkle both sides of each tilapia fillet evenly with the prepared seasoning mixture, pressing gently so the spices adhere.
03 - For a crispier crust, lightly dredge the seasoned fillets in cornmeal or gluten-free flour, shaking off any excess.
04 - Heat the olive oil or butter in a large nonstick skillet over medium-high heat until the fat shimmers and the pan is evenly coated.
05 - Carefully place the fillets in the hot skillet, working in batches if necessary to avoid crowding. Cook for 3–4 minutes on the first side until the underside is golden and the fish releases easily from the pan.
06 - Gently flip each fillet and continue cooking for another 2–3 minutes until the fish is completely opaque and flakes easily when tested with a fork.
07 - Transfer the cooked fillets to serving plates immediately and garnish with fresh lemon wedges for squeezing over the fish.