01 - Generously season beef chunks with salt and black pepper.
02 - Heat olive oil in a large heavy-bottomed pot over medium-high heat. Sear beef in batches until browned on all sides. Transfer to a plate.
03 - Add onion, carrots, and celery to the pot. Cook, stirring occasionally, for 6 to 8 minutes until softened. Add garlic and cook for 1 minute more.
04 - Stir in tomato paste and cook for 2 minutes. Deglaze with red wine, scraping up browned bits from the pot. Simmer for 2 to 3 minutes until slightly reduced.
05 - Return seared beef to the pot. Add crushed tomatoes, beef stock, oregano, thyme, bay leaves, and optional red pepper flakes. Stir well and bring to a gentle simmer.
06 - Cover and cook on low heat for 3 hours, stirring occasionally, until beef is fork-tender and sauce is thickened. Skim off excess fat as needed.
07 - Remove bay leaves. Shred beef directly in the sauce using two forks. Taste and adjust seasoning with salt and pepper as necessary.
08 - Bring a large pot of salted water to a boil. Cook pappardelle until al dente according to package instructions. Reserve ½ cup of pasta water, then drain pasta.
09 - Toss cooked pasta with the beef ragu, adding reserved pasta water as needed to reach desired consistency.
10 - Plate the pasta and ragu mixture. Garnish with freshly grated Parmigiano-Reggiano and chopped fresh basil or parsley. Serve immediately.